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Thread: Bone Marrow Transplant May Cure the AIDS

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    Going home soon... Nisha7's Avatar Nisha7 is offline
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    Bone Marrow Transplant May Cure the AIDS

    BERLIN - An American man who suffered from AIDS appears to have been cured of the disease 20 months after receiving a targeted bone marrow transplant normally used to fight leukemia, his doctors said.

    While researchers — and the doctors themselves — caution that the case might be no more than a fluke, others say it may inspire a greater interest in gene therapy to fight the disease that claims 2 million lives each year. The virus has infected 33 million people worldwide.

    Dr. Gero Huetter said Wedneday his 42-year-old patient, an American living in Berlin who was not identified, had been infected with the AIDS virus for more than a decade. But 20 months after undergoing a transplant of genetically selected bone marrow, he no longer shows signs of carrying the virus.

    "We waited every day for a bad reading," Huetter said.

    It has not come. Researchers at Berlin's Charite hospital and medical school say tests on his bone marrow, blood and other organ tissues have all been clean.

    However, Dr. Andrew Badley, director of the HIV and immunology research lab at the Mayo Clinic in Rochester, Minn., said those tests have probably not been extensive enough.

    "A lot more scrutiny from a lot of different biological samples would be required to say it's not present," Badley said.

    This isn't the first time marrow transplants have been attempted for treating AIDS or HIV infection. In 1999, an article in the journal Medical Hypotheses reviewed the results of 32 attempts reported between 1982 and 1996. In two cases, HIV was apparently eradicated, the review reported.

    Huetter's patient was under treatment at Charite for both AIDS and leukemia, which developed unrelated to HIV.

    As Huetter — who is a hematologist, not an HIV specialist — prepared to treat the patient's leukemia with a bone marrow transplant, he recalled that some people carry a genetic mutation that seems to make them resistant to HIV infection. If the mutation, called Delta 32, is inherited from both parents, it prevents HIV from attaching itself to cells by blocking CCR5, a receptor that acts as a kind of gateway.

    "I read it in 1996, coincidentally," Huetter told reporters at the medical school. "I remembered it and thought it might work."

    Roughly one in 1,000 Europeans and Americans have inherited the mutation from both parents, and Huetter set out to find one such person among donors that matched the patient's marrow type. Out of a pool of 80 suitable donors, the 61st person tested carried the proper mutation.

    Before the transplant, the patient endured powerful drugs and radiation to kill off his own infected bone marrow cells and disable his immune system — a treatment fatal to between 20 and 30 percent of recipients.

    He was also taken off the potent drugs used to treat his AIDS. Huetter's team feared that the drugs might interfere with the new marrow cells' survival. They risked lowering his defenses in the hopes that the new, mutated cells would reject the virus on their own.

    Anthony Fauci, director of the National Institute of Allergy and Infections Diseases in the U.S., said the procedure was too costly and too dangerous to employ as a firstline cure. But he said it could inspire researchers to pursue gene therapy as a means to block or suppress HIV.

    "It helps prove the concept that if somehow you can block the expression of CCR5, maybe by gene therapy, you might be able to inhibit the ability of the virus to replicate," Fauci said.

    David Roth, a professor of epidemiology and international public health at the London School of Hygiene and Tropical Medicine, said gene therapy as cheap and effective as current drug treatments is in very early stages of development.

    "That's a long way down the line because there may be other negative things that go with that mutation that we don't know about."

    Even for the patient in Berlin, the lack of a clear understanding of exactly why his AIDS has disappeared means his future is far from certain.

    "The virus is wily," Huetter said. "There could always be a resurgence."
    Doctors say marrow transplant may have cured AIDS on Yahoo! Health

    Dont mind me Im on an early morning phone conference...steuppps

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    Registered User Mrs. Skilz™ is offline
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    you know ah heard dat on d news last night...great if its true now if they could find a cure for d real fackin killa CANCER of all forms....

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    Registered User RotiKing2004eva is offline
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    Quote Originally Posted by kandygirl View Post
    you know ah heard dat on d news last night...great if its true now if they could find a cure for d real fackin killa cancer of all forms....
    +1

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    Temporary Suspension Swerve is offline
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    Idle.. LOL.
    Interesting read though..
    Would be nice if they found a cure of aids/hiv so we have one less thing to worry about...

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    Going home soon... Nisha7's Avatar Nisha7 is offline
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    Quote Originally Posted by Swervin View Post
    Idle.. LOL.
    Interesting read though..
    Would be nice if they found a cure of aids/hiv so we have one less thing to worry about...
    Whateva, I been in a faculty senate meeting since 7:30 this morning...7:30!!!! Who plans to do anything work related at 7:30 and dese fackers still going...Im ready to go back to bed.

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    where de crix Oneshot's Avatar Oneshot is offline
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    Nisha lets make soe Delta 32, gene babies and save the world

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    Super Moderator Jason kiDD's Avatar Jason kiDD is offline
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    AIDS is man made. Population control. Only when they running low on moneies will they release the "cure" and then charge you triple for it.. :

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    Going home soon... Nisha7's Avatar Nisha7 is offline
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    Quote Originally Posted by Oneshot View Post
    Nisha lets make soe Delta 32, gene babies and save the world
    OK did I not say, I in a phone conference..you got me laughing out loud...all these braniacs think I finally lost it. BTW, we need to debrief

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    Temporary Suspension Swerve is offline
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    Quote Originally Posted by PJK View Post
    AIDS is man made. Population control. Only when they running low on moneies will they release the "cure" and then charge you triple for it.. :
    Gubment conspiracy Theory..

    and Magic Johnson never had aids.. was just part of the overall conspiracy to terrify the world..and spur big pharmaceutical businesses

    (I'm juss talking sh!t folks)

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    where de crix Oneshot's Avatar Oneshot is offline
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    Quote Originally Posted by Nisha7 View Post
    OK did I not say, I in a phone conference..you got me laughing out loud...all these braniacs think I finally lost it. BTW, we need to debrief
    being crazy is a disability a black, female, disabled worker.. you cannot be fired, i just made you recession proof.

    recognize!!!

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    Going home soon... Nisha7's Avatar Nisha7 is offline
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    Quote Originally Posted by Oneshot View Post
    being crazy is a disability a black, female, disabled worker.. you cannot be fired, i just made you recession proof.

    recognize!!!
    Gee thanks

    Dont know if temporary insanity counts, but if so I could get our friend to write me a drs. note for a mental health vacay, so I could come rehab in London and still keep my job.

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    where de crix Oneshot's Avatar Oneshot is offline
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    Quote Originally Posted by Nisha7 View Post
    Gee thanks

    Dont know if temporary insanity counts, but if so I could get our friend to write me a drs. note for a mental health vacay, so I could come rehab in London and still keep my job.
    LOL.. consider it organized.. BTW PM me the digits

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    Going home soon... Nisha7's Avatar Nisha7 is offline
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    Quote Originally Posted by Oneshot View Post
    LOL.. consider it organized.. BTW PM me the digits
    Yuh got early onset alzheimers or wha?

    Meeting finally over, going to the gym and taking my ass back to bed...

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    aka Tiny-Winey reppin SIA Pretty Preya's Avatar Pretty Preya is offline
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    Bone Marrow transplant cures man of aids....

    i dont kknow how i feel about this honestly....i think its just going to create drama...a mas of ppl are going to line up to get this done just cuz it worked for 1 body
    Last edited by Pretty Preya; 11-13-2008 at 11:51 AM.

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    Registered User kitkat75's Avatar kitkat75 is offline
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    Quote Originally Posted by PJK View Post
    AIDS is man made. Population control. Only when they running low on moneies will they release the "cure" and then charge you triple for it.. :
    PJK I said the samething it's manmade, but before they could release the cure they have to study the disease to see what the symtoms are, how the human body reacts to it and how it affect the body all this they have to know before the could release the cure, but I think it just spread to fast for the scientists to keep up.

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